Natalie MacMaster and her musical partner Donnell Leahy play several tunes from the Cape Breton tradition -- a sprightly, soulful style of folk fiddling. It's an inspired collaboration that will have you clapping (and maybe dancing) along.

Biochemist Joe DeRisi talks about amazing new ways to diagnose viruses (and treat the illnesses they cause) using DNA. His work may help us understand malaria, SARS, avian flu -- and the 60 percent of everyday viral infections that go undiagnosed.

Biochemist Joe DeRisi talks about amazing new ways to diagnose viruses (and treat the illnesses they cause) using DNA. His work may help us understand malaria, SARS, avian flu -- and the 60 percent of everyday viral infections that go undiagnosed.

Biochemist Joe DeRisi talks about amazing new ways to diagnose viruses (and treat the illnesses they cause) using DNA. His work may help us understand malaria, SARS, avian flu -- and the 60 percent of everyday viral infections that go undiagnosed.

In this TED archive video from 1998, paralympic sprinter Aimee Mullins talks about her record-setting career as a runner, and about the amazing carbon-fiber prosthetic legs (then a prototype) that helped her cross the finish line.

In this TED archive video from 1998, paralympic sprinter Aimee Mullins talks about her record-setting career as a runner, and about the amazing carbon-fiber prosthetic legs (then a prototype) that helped her cross the finish line.

Asteroid strikes get all the coverage, but "Medea Hypothesis" author Peter Ward argues that most of Earth's mass extinctions were caused by lowly bacteria. The culprit, a poison called hydrogen sulfide, may have an interesting application in medicine.

Asteroid strikes get all the coverage, but "Medea Hypothesis" author Peter Ward argues that most of Earth's mass extinctions were caused by lowly bacteria. The culprit, a poison called hydrogen sulfide, may have an interesting application in medicine.

Asteroid strikes get all the coverage, but "Medea Hypothesis" author Peter Ward argues that most of Earth's mass extinctions were caused by lowly bacteria. The culprit, a poison called hydrogen sulfide, may have an interesting application in medicine.

Woody Norris shows off two of his inventions that treat sound in new ways, and talks about his untraditional approach to inventing and education. As he puts it: "Almost nothing has been invented yet." So -- what's next?

Woody Norris shows off two of his inventions that treat sound in new ways, and talks about his untraditional approach to inventing and education. As he puts it: "Almost nothing has been invented yet." So -- what's next?

Woody Norris shows off two of his inventions that treat sound in new ways, and talks about his untraditional approach to inventing and education. As he puts it: "Almost nothing has been invented yet." So -- what's next?

Surgeon and writer Sherwin Nuland meditates on the idea of hope -- the desire to become our better selves and make a better world. It's a thoughtful 12 minutes that will help you focus on the road ahead.

Surgeon and writer Sherwin Nuland meditates on the idea of hope -- the desire to become our better selves and make a better world. It's a thoughtful 12 minutes that will help you focus on the road ahead.

What is genomics? How will it affect our lives? In this intriguing primer on the genomics revolution, entrepreneur Barry Schuler says we can at least expect healthier, tastier food. He suggests we start with the pinot noir grape, to build better wines.

What is genomics? How will it affect our lives? In this intriguing primer on the genomics revolution, entrepreneur Barry Schuler says we can at least expect healthier, tastier food. He suggests we start with the pinot noir grape, to build better wines.

We all want to make the world better -- but how? Jamais Cascio looks at some specific tools and techniques that can make a difference. It's a fascinating talk that might just inspire you to act.

We all want to make the world better -- but how? Jamais Cascio looks at some specific tools and techniques that can make a difference. It's a fascinating talk that might just inspire you to act.

Great design is a never-ending journey of discovery -- for which it helps to pack a healthy sense of humor. Sociologist and surfer-turned-designer David Carson walks through a gorgeous (and often quite funny) slide deck of his work and found images.

Paula Scher looks back at a life in design (she's done album covers, books, the Citibank logo ...) and pinpoints the moment when she started really having fun. Look for gorgeous designs and images from her legendary career.